2001 Mar 15;126(6):158-65. However, since vaccine preparation involves the use of materials of biological origin, vaccines are subject to contamination by micro-organisms. Epub 2010 Mar 25. In fact, vaccine contamination has occurred; a historical example of vaccine contam … These incidents have lead industry to change certain practices and regulatory authorities to develop more stringent and detailed requirements. In fact, vaccine contamination has occurred; a historical example of vaccine contamination, for example, can be found in the early days of development of the smallpox vaccine.
Certain antibiotics may be used in some vaccine production to help prevent bacterial contamination during manufacturing. COVID-19 is an emerging, rapidly evolving situation. Epub 2012 May 9. van der Kuyl AC, Cornelissen M, Berkhout B. Testing for viral contaminants of veterinary vaccines in Hungary. The introduction of new techniques of vaccine virus production on cell cultures has lead to safer vaccines, but has not completely removed the risk of virus contamination. NIH Tijdschr Diergeneeskd. But the increasing number of target species for vaccines, the diversity of the origin of biological materials and the extremely high number of known and unknown viruses and their constant evolution represent a challenge to vaccine producers and regulatory authorities. doi: 10.1371/journal.pone.0082217. Most of the contamination was in the inactivated polio vaccine (IPV), but it was also found in oral polio vaccine (OPV). Current challenges in viral safety and extraneous agent testing.
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Wei K, Sun Z, Zhu S, Guo W, Sheng P, Wang Z, Zhao C, Zhao Q, Zhu R. PLoS One. 2010 May;38(3):335-7. doi: 10.1016/j.biologicals.2010.01.014. Epub 2010 Mar 24. We use cookies to help provide and enhance our service and tailor content and ads. Vaccination is one of the most important public health accomplishments. HHS 2012 Jul;40(4):225-30. doi: 10.1016/j.biologicals.2012.04.004. The Fluad vaccine, a flu vaccine licensed for adults aged 65 years and older, contains an adjuvant called MF59, which is an oil-in-water emulsion containing squalene. 2013 Dec 12;8(12):e82217. Soon after this initial finding, XMRV was also detected in samples from patients with chronic fatigue syndrome (CFS). The xenotropic murine leukemia virus-related virus (XMRV) was first found in samples from a human prostate tumor in 2006. ► No evidence of XMRV infection in humans.
The … Epub 2010 Mar 23. 2011 Jan 17;1:147. doi: 10.3389/fmicb.2010.00147. The association with human disease was probably due to contamination of samples. Please enable it to take advantage of the complete set of features! 56.
Nonetheless, concerns have been raised regarding contamination of human vaccines as a possible source of introduction of XMRV … The initial associations of XMRV with chronic fatigue syndrome and prostate cancer, while providing much hope and optimism, have now been discredited and/or retracted following overwhelming evidence that (1) numerous patient cohorts from around the world are XMRV-negative, (2) the initial reports of XMRV-positive patients were due to contamination with mouse DNA, XMRV plasmid DNA, or virus from the 22Rv1 cell line and (3) XMRV is a laboratory-derived virus generated in the mid 1990s through recombination during passage of a prostate tumor xenograft in immuno-compromised mice. eCollection 2013. This site needs JavaScript to work properly. 2019 Sep 5;19(1):778. doi: 10.1186/s12879-019-4398-0.
Google Scholar. NLM The discovery and de-discovery of the xenotropic murine leukemia virus-related virus (XMRV) has been a tumultuous roller-coaster ride for scientists and patients. It was reported to be present in 6% to 27% of human prostate cancers. Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines. Several veterinary vaccines have been contaminated by pestiviruses from foetal calf serum. XMRV can infect human cells. ► Mouse DNA contamination is abundant. As a result, small amounts of antibiotics may be present in some vaccines. However, since vaccine preparation involves the use of materials of biological origin, vaccines are subject to contamination by micro-organisms. doi: 10.1371/journal.pone.0043422. Extraneous agent detection in vaccines--a review of technical aspects. Barkema HW, Bartels CJ, van Wuijckhuise L, Hesselink JW, Holzhauer M, Weber MF, Franken P, Kock PA, Bruschke CJ, Zimmer GM. Biologicals. ► XMRV is a laboratory-derived virus. | ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Recombinant origin, contamination, and de-discovery of XMRV, https://doi.org/10.1016/j.coviro.2012.06.009. While these developments are disappointing to scientists and patients, they provide a valuable road map of potential pitfalls to the would-be microbe hunters. Biologicals.
Yang K, Jiao Z, Zhou D, Guo R, Duan Z, Tian Y. BMC Infect Dis. In 2006, a new virus, xenotropic murine leukemia virus-related virus (XMRV), was discovered in a cohort of U.S. men with prostate cancer. Yet another potential source of contamination is the XMRV virus produced from the 22Rv1 cell line, ... W. HeneineNo evidence of murine leukemia virus-related viruses in live attenuated human vaccines. Aziz-Boaron O, Leibovitz K, Gelman B, Kedmi M, Klement E. PLoS One. Epub 2012 Aug 17. Development of a multiplex PCR to detect and discriminate porcine circoviruses in clinical specimens. Clipboard, Search History, and several other advanced features are temporarily unavailable. ► XMRV is not linked to CFS or prostate cancer.
2012;7(8):e43422. Front Microbiol. [Outbreak of bovine virus diarrhea on Dutch dairy farms induced by a bovine herpesvirus 1 marker vaccine contaminated with bovine virus diarrhea virus type 2]. Biologicals. By continuing you agree to the use of cookies. Viral safety and extraneous agents testing for veterinary vaccines: rationale for requirements, the European approach. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. A study in 2009 also found XMRV in the blood of 67% of people with CFS. Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus which was first described in 2006 as an apparently novel human pathogen found in tissue samples from men with prostate cancer. Although XMRV was originally described as infecting human prostate stromal cells (Urisman et al., 2006), in vitro assays show that the virus can infect and replicate in various human, feral mouse, mink, monkey and bovine cell lines (Stieler et al., 2010). 2010 May;38(3):338-9. doi: 10.1016/j.biologicals.2010.01.008. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Background The association of xenotropic murine leukemia virus (MLV)-related virus (XMRV) in prostate cancer and chronic fatigue syndrome reported in previous studies remains controversial as these results have been questioned by recent data. eCollection 2010. Increasingly, the word contamination was bubbling up in scientific articles and blogs to account for both the XMRV and the MLV-like virus findings. Copyright © 2020 Elsevier B.V. or its licensors or contributors. PLoS ONE, 6 (2011), p. e29223.
Dodet B, Hesselink W, Jungbäck C, Léchenet J, Pastoret PP, Vannier P, Vicari M. Biologicals. The virus came from monkey kidney cell cultures used to make polio vaccines at that time. There are several examples of vaccine contamination, for example, contamination of human vaccines against poliomyelitis by SV40 virus from the use of monkey primary renal cells. Viral safety and extraneous agents testing for veterinary vaccines. 2010 May;38(3):346-9. doi: 10.1016/j.biologicals.2010.01.007. Biologicals. From 1955 to 1963, an estimated 10-30% of polio vaccines administered in the US were contaminated with simian virus 40 (SV40). Vaccination is one of the most important public health accomplishments. Safety, immunogenicity and duration of immunity elicited by an inactivated bovine ephemeral fever vaccine.
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