2017;2017:8379843. Herein, two clinical small molecular drugs, celastrol (CST) and doxorubicin (DOX), were self-assembled into carrier-free and biocompatible nanoparticles (CST/DOX NPs) via a simple and green precipitation method for synergistic combination chemotherapy to overcome DOX resistance. zhangzj@ucas.edu.cn, c CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellent in Nanoscience, National Center for Nanoscience and Technology of China, University of Chinese Academy of Sciences, Beijing 100190, China Interstitial therapy, delivery of chemotherapy locally to the tumor site, via a biodegradable polymer implant can overcome the blood-brain barrier and increase the range of drugs available for therapy. Med Chem. Thus, CST/DOX NPs provide an alternative for overcoming drug resistance in future clinical applications. 2019 Aug;8(9):4315-4329. You do not have JavaScript enabled. E-mail: Instructions for using Copyright Clearance Center page for details. Thus, CST/DOX NPs provide an alternative for overcoming drug resistance in future clinical applications. Modified Citrus Pectin’s benefits extend far beyond cancer, as new research continues to expand the number of conditions where MCP can make a life-changing difference. Glioblastoma (GBM) is a highly aggressive and heterogeneous form of brain cancer.
Certain natural ingredients demonstrate greater synergistic abilities than others. Combination chemotherapy could overcome drug resistance; however, GBM's location behind the blood-brain barrier severely limits chemotherapeutic options. Boosting the Benefits of Other Herbs And Supplements, Improving Radiation Treatment with Supplements, Reducing Antibiotic Resistance with Supplements, The Secret to Modified Citrus Pectin’s Success, DIM — The Powerhouse Phytonutrient for Breast Cancer Prevention and Treatment, Mold Toxins—A Hidden Threat to Health and Vitality, The Ultimate Guide to Modified Citrus Pectin. or in a thesis or dissertation provided that the correct acknowledgement is given Modified Citrus Pectin enhances chemotherapy, even against resistant cancers, and protects against damage from radiation treatment. Since MCP has powerful synergistic enhancement abilities with both conventional and natural treatments, it’s a fundamental cornerstone in my recommendations for overcoming cancer and chronic diseases and regaining optimal vitality. Please enable JavaScript 2013;14(12):7561-8.
with the reproduced material. Modified Citrus Pectin can do this while providing a plethora of benefits on its own—making it one of the most essential supplements for anyone seeking greater health and vitality. 2017;13(7):682-688. This work illustrates the advantages of synchronized interstitial therapy of paclitaxel and everolimus for post-surgical tumor control of GBM. If you are the author of this article you do not need to formally request permission This may take some time to load. Dahdouh E, El-Khatib S, Baydoun E, Abdel-Massih RM. contained in this article in third party publications Synergistic treatment combinations are also key to successful integrative medicine—the integration of diverse medical systems and approaches to achieve optimal results. One cell study showed that the combination of MCP with the antibiotic drug, cefotaxime, produced greater efficacy against methicillin-resistant Staphylococcus aureus (MRSA) strains. Hossein G, Halvaei S, Heidarian Y, Dehghani-Ghobadi Z, Hassani M, Hosseini H, Naderi N, Sheikh Hassani S. Cancer Med. 3. 7. The combination of nitazoxanide, an FDA-approved drug, and remdesivir, FDA emergency use authorization for the treatment of COVID-19, demonstrate a strong synergistic interaction. Combination interstitial therapy of both paclitaxel and everolimus significantly reduced GBM growth and improved progression free survival in two clinically relevant orthotopic models of GBM resection and recurrence. If you are not the author of this article and you wish to reproduce material from
One important cell study showed that MCP made prostate cancer cells more sensitive to radiation treatment. 2012 Jul;36(7):601-10. If we can find a way to make life-saving treatments more effective, at lower doses (meaning fewer side effects), it can be a game-changer, especially for patients with limited options. 2013;12(2):145-152. These two formulas for breast and prostate cancer have both been shown in multiple studies to reduce tumor growth and prevent metastasis. https://doi.org/10.1016/j.jconrel.2020.04.028. In medicine, synergy is when a combination of two or more things — such as drugs, natural compounds, therapies, and treatments — produces significantly greater results compared to using each one alone. Synergistic Antioxidant and Anti-Inflammatory Effects between Modified Citrus Pectin and Honokiol. This is the true alchemy of medicine, and medical researchers continue to discover powerful synergistic combinations that offer advanced benefits.
Data shows the ability of MCP to increase the effectiveness of these treatments, allowing for lower dosages with greater benefits. These results demonstrate the ability of MCP to enhance the cancer-killing actions of radiation treatment, help overcome cancer radiation treatment resistance, and significantly reduce the radiation dose necessary to achieve results—leading to fewer side effects.4. What makes MCP so effective as a synergistic enhancer, while also standing on its own as a potent therapeutic agent for our most critical conditions? School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China The strong synergism seen with paclitaxel and everolimus was then explored in vivo. Similarly, eating broccoli with tomatoes is shown to enhance the disease-fighting effects of both vegetables. Ideal drug candidates for interstitial therapy are those that are potent against GBM and work in combination with both standard-of-care therapy and new precision medicine targets. Reproduced material should be attributed as follows: If the material has been adapted instead of reproduced from the original RSC publication of the whole article in a thesis or dissertation. 2018 Dec;17(4):1225-1234. Additionally, by selecting a drug combination that takes into account individual variability due to tumor heterogenicity and molecular profiling, a precision medicine approach can be delivered [ 24 ]. to reproduce figures, diagrams etc. It could even equal 100 or more. 2017;2017:8379843. Paclitaxel and everolimus were separately formulated into fibrous scaffolds composed of acetalated dextran, a biodegradable polymer with tunable degradation rates, for implantation in the brain.
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